选择语言
免费注册
关注公众号
微信客服

FAP

FAP信息

英文名称:Prolyl endopeptidase FAP上市药物数量0
中文名称成纤维细胞激活蛋白α临床药物数量45
靶点别称Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP最高研发阶段临床二期
英文名称:Prolyl endopeptidase FAP
中文名称成纤维细胞激活蛋白α
靶点别称Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP
上市药物数量0
临床药物数量45
最高研发阶段Phase 2 Clinical

FAP产品列表

  • 属性

    Protein (13)Beads (1)Cell (1)

  • 产品库

    在线 (15)

  • 物种

    Human (9)Cynomolgus (2)Mouse (2)Rat (1)Canine (1)

  • 标签

    His Tag (7)Fc Tag (2)His Tag & Avi Tag (4)- (2)

  • 标记

    Unconjugated (5)FITC Labeled (2)Biotin-labeled (4)PE Labeled (1)- (2)AF647 Labeled (1)

共 15 项数据
  • 1
  • 2

FAP分子背景

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP分子别名

FAP,FAPalpha,SIMP,Seprase,APCE

产品评论

  • 2026-04-07
    0人点赞
    Mouse FAP Protein, His Tag, active dimer (MALS verified)
    产品包装完美，小盒包装也精美，扫码查询COA也方便，一如既往的支持，希望贵公司越来越壮大，发展越来越好！希望贵公司苏州分部也蒸蒸日上，人员规模和利润再上一个新台阶！
  • ka*****huabobio.com 2026-03-28
    1人点赞
    Rat FAP Protein, His Tag, active dimer (MALS verified)
    终于在Acro这找到了大鼠的FAP，下单后很快就到货了，复溶迅速且清澈。在SPR亲和力检测中效果不错。
  • 2026-03-11
    1人点赞
    Human FAP Protein, His Tag, active dimer, low endotoxin (MALS verified)
    Human FAP Protein, His Tag, active dimer (MALS verified) 蛋白包装精美，用于酶切实验的酶活较好，能够迅速切割裂解底物。 图注：图1阳性底物被迅速酶解；图2 在0.67h时保留时间为12.9min的原料基本都反应完，生成断裂产物。
加载更多
  • 分子信息
  • 产品列表