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Dkk-3

Dkk-3信息

英文名称:Dickkopf-related protein 3上市药物数量0
中文名称Dickkopf相关蛋白3临床药物数量1
靶点别称Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG最高研发阶段临床二期
英文名称:Dickkopf-related protein 3
中文名称Dickkopf相关蛋白3
靶点别称Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

Dkk-3产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Mouse (1)Human (1)

  • 标签

    His Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

Dkk-3分子背景

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3分子别名

DKK3,REIC,RIG
  • 分子信息
  • 产品列表