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CXADR

CXADR信息

英文名称:Calcium sensing receptor上市药物数量6
中文名称钙敏感受体临床药物数量5
靶点别称Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1最高研发阶段批准上市
英文名称:Calcium sensing receptor
中文名称钙敏感受体
靶点别称Parathyroid cell calcium-sensing receptor 1，FHH，FIH，HHC，Receptors， Calcium-Sensing，Extracellular calcium-sensing receptor，hCasR，GPRC2A，Calcium Sensing Receptor，Parathyroid Ca(2+)-Sensing Receptor 1，Severe Neonatal Hyperparathyroidism，Calcium-Sensing Receptor，HYPOC1，NSHPT，PCaR1，EIG8，HHC1，CaSR，CAR，Hypocalciuric Hypercalcemia 1
上市药物数量6
临床药物数量5
最高研发阶段Approved

CXADR产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

CXADR分子背景

Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V­ type (D1) and a C2­ type (D2) Ig­like domain, a  transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

CXADR分子别名

CXADR,CAR,CAR4,6,HCAR
  • 分子信息
  • 产品列表