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Clusterin

Clusterin信息

英文名称:Clusterin上市药物数量0
中文名称丛生蛋白临床药物数量1
靶点别称Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2最高研发阶段临床二期
英文名称:Clusterin
中文名称丛生蛋白
靶点别称Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

Clusterin产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

Clusterin分子背景

Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N­glycosylated disulfide­linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Clusterin分子别名

CLU,Clusterin,AAG4,APOJ,CLI,KUB1,SGP-2,SP-40,TRPM2
  • 分子信息
  • 产品列表