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CLEC7A

CLEC7A信息

英文名称:C-type lectin domain family 7 member A上市药物数量0
中文名称C型凝集素域7家族成员A临床药物数量1
靶点别称C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A最高研发阶段临床阶段不明
英文名称:C-type lectin domain family 7 member A
中文名称C型凝集素域7家族成员A
靶点别称C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A
上市药物数量0
临床药物数量1
最高研发阶段Clinical

CLEC7A产品列表

  • 属性

    Protein (3)

  • 产品库

    在线 (3)

  • 物种

    Human (2)Cynomolgus (1)

  • 标签

    His Tag (3)

  • 标记

    Unconjugated (3)

共 3 项数据
  • 1

CLEC7A分子背景

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).

CLEC7A分子别名

BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2

产品评论

  • tm*****sina.cn 2025-06-17
    0人点赞
    Human CLEC7A Protein, His Tag
    Acro这个蛋白的纯度非常好，该蛋白大小只有17.5kd，长短选取合适。活性符合实验要求，我们买来用作抗体结合的ELISA相关实验，是延安曲线表明数据质量和信号很好，满足筛选和评价需要。推荐大家购买。
  • 分子信息
  • 产品列表