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B7-H4

B7-H4信息

英文名称:V-set domain-containing T-cell activation inhibitor 1上市药物数量0
中文名称含V区域T细胞激活抑制因子1临床药物数量10
靶点别称V-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1最高研发阶段临床三期
英文名称:V-set domain-containing T-cell activation inhibitor 1
中文名称含V区域T细胞激活抑制因子1
靶点别称V-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1
上市药物数量0
临床药物数量10
最高研发阶段Phase 3 Clinical

B7-H4产品列表

  • 属性

    Protein (10)Cell (1)

  • 产品库

    在线 (11)

  • 物种

    Human (5)Mouse (2)Cynomolgus / Rhesus macaque (2)Rat (1)Canine (1)

  • 标签

    His Tag (7)His Tag & Avi Tag (2)Fc Tag (1)- (1)

  • 标记

    Biotin-labeled (3)Unconjugated (6)Azide Labeled (1)- (1)

共 11 项数据
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B7-H4分子背景

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

B7-H4分子别名

B7-H4,VTCN1,B7S1,B7h.5

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