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Apo-A1

Apo-A1信息

英文名称:Apolipoprotein A-I上市药物数量0
中文名称载脂蛋白A-I临床药物数量3
靶点别称Epididymis Secretory Sperm Binding Protein，Apolipoprotein A-I(1-242)，APOA1，ProapoA-I，Apo-AI，Apolipoprotein A1，Apo(A)，ApoA-I，Apolipoprotein A-I，HPALP2最高研发阶段临床二期
英文名称:Apolipoprotein A-I
中文名称载脂蛋白A-I
靶点别称Epididymis Secretory Sperm Binding Protein，Apolipoprotein A-I(1-242)，APOA1，ProapoA-I，Apo-AI，Apolipoprotein A1，Apo(A)，ApoA-I，Apolipoprotein A-I，HPALP2
上市药物数量0
临床药物数量3
最高研发阶段Phase 2 Clinical

Apo-A1产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

Apo-A1分子背景

ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

Apo-A1分子别名

Apolipoprotein A-I,APOA1,MGC117399
  • 分子信息
  • 产品列表