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ALK-1

ALK-1信息

英文名称:Activin receptor-like kinase 1上市药物数量0
中文名称激活素受体样激酶-1临床药物数量1
靶点别称EC:2.7.11.30，ACVRLK1，Activin A Receptor Type II-Like 1，Activin A Receptor， Type II-Like Kinase 1，EC 2.7.11，ALK-1，Serine/threonine-protein kinase receptor R3，TGF-B superfamily receptor type I，Activin receptor-like kinase 1，SKR3，ALK1，ACVRL1，Activin A Receptor Like Type 1，Activin A Receptor Type IL，TSR-I，EC 2.7.11.30，HHT2，ORW2，HHT最高研发阶段临床二期
英文名称:Activin receptor-like kinase 1
中文名称激活素受体样激酶-1
靶点别称EC:2.7.11.30，ACVRLK1，Activin A Receptor Type II-Like 1，Activin A Receptor， Type II-Like Kinase 1，EC 2.7.11，ALK-1，Serine/threonine-protein kinase receptor R3，TGF-B superfamily receptor type I，Activin receptor-like kinase 1，SKR3，ALK1，ACVRL1，Activin A Receptor Like Type 1，Activin A Receptor Type IL，TSR-I，EC 2.7.11.30，HHT2，ORW2，HHT
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

ALK-1产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

ALK-1分子背景

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.

ALK-1分子别名

ACVRL1,ACVRLK1,ALK-1,HHT,HHT2,ORW2,SKR3,TSR-I
  • 分子信息
  • 产品列表