Activin E

Activins are one of the three distinct subclasses within the greater Transforming growth factor β superfamily. The members of the activin subclass include activin A, activin B, activin C, activin E, and the more distant members myostatin and GDF-11. Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis.