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4-1BB

4-1BB信息

英文名称:Tumor necrosis factor receptor superfamily member 9上市药物数量0
中文名称肿瘤坏死因子受体超家族成员9临床药物数量74
靶点别称TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB最高研发阶段临床二期
英文名称:Tumor necrosis factor receptor superfamily member 9
中文名称肿瘤坏死因子受体超家族成员9
靶点别称TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB
上市药物数量0
临床药物数量74
最高研发阶段Phase 2 Clinical

4-1BB产品列表

  • 属性

    Protein (19)Cell (2)Antibody (1)

  • 产品库

    在线 (22)

  • 物种

    Cynomolgus / Rhesus macaque (2)Human (14)Mouse (3)Rabbit (1)Rat (1)Canine (1)

  • 标签

    His Tag (7)Fc Tag (4)Mouse IgG Fc Tag (1)His Tag & Avi Tag (5)Fc Tag & Avi Tag (1)- (2)Mouse IgG1 (1)Tag Free (1)

  • 标记

    Unconjugated (14)Biotin-labeled (6) (2)

共 22 项数据
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4-1BB分子背景

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

4-1BB分子别名

TNFRSF9,4-1BB,CD137,CDw137,ILA

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