选择语言
免费注册
关注公众号
微信客服

4-1BB

4-1BB信息

英文名称:Tumor necrosis factor receptor superfamily member 9上市药物数量0
中文名称肿瘤坏死因子受体超家族成员9临床药物数量74
靶点别称TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB最高研发阶段临床二期
英文名称:Tumor necrosis factor receptor superfamily member 9
中文名称肿瘤坏死因子受体超家族成员9
靶点别称TNFRSF9，T-cell antigen ILA，ILA，TNF Receptor Superfamily Member 9，T-Cell Antigen 4-1BB Homolog，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Tumor Necrosis Factor Receptor Superfamily Member 9，Induced By Lymphocyte Activation (ILA)，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA，4-1BB
上市药物数量0
临床药物数量74
最高研发阶段Phase 2 Clinical

4-1BB产品列表

  • 属性

    Protein (20)Cell (2)Antibody (3)Kits (1)

  • 产品库

    在线 (26)

  • 物种

    Cynomolgus / Rhesus macaque (2)Human (18)Mouse (3)Rabbit (1)Rat (1)Canine (1)

  • 标签

    His Tag (8)Fc Tag (4)Mouse IgG Fc Tag (1)His Tag & Avi Tag (5)Fc Tag & Avi Tag (1)- (3)Mouse IgG1 (3)Tag Free (1)

  • 标记

    Unconjugated (16)Biotin-labeled (6)- (3)PE Labeled (1)

共 26 项数据
  • 1
  • 2
  • 3

4-1BB分子背景

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

4-1BB分子别名

TNFRSF9,4-1BB,CD137,CDw137,ILA

产品评论

  • ya**********qq.com 2025-10-21
    0人点赞
    Mouse 4-1BB / TNFRSF9 Protein, His Tag
    1，蛋白活性好，溶解后分装冻存没问题，活性可以重复。2，实验结果重复性好，冻融活性无影响。3，用于活性分析实验。非常好的实验结果。4，包装盒精美，物流速度很快，很期待哦
  • 15********qq.com 2025-09-29
    0人点赞
    Human 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
    该货号的TNFRSF9蛋白是我们组抗体项目研发过程中经常用到的一款蛋白，多批次蛋白ELISA活性检测结果显示，蛋白与阳性抗体结合亲和力均在同一数量级，质量稳定性极佳。
  • 21********qq.com 2025-09-24
    0人点赞
    Human 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)
    使用该蛋白主要用于抗体库的筛选及亲和力检测，蛋白特异性强，获得的候选抗体分子亲和力EC50数据很棒，结合曲线也非常完美。性价比也高，值得推荐。
加载更多
  • 分子信息
  • 产品列表