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官方服务号
招聘公众号
生物工艺号
| 分子 | 生物学功能 |
|---|---|
| KLK1 | 血管舒缓素系统相关，调控血压与炎症反应 |
| KLK4, KLK10, KLK11 | 调节上皮细胞增殖、分化与凋亡，涉及肿瘤发生发展 |
| KLK6 | 参与中枢神经系统的炎症与神经退行性疾病过程 |
| KLK2, KLK3 | 前列腺癌的生物标志物 / 靶向治疗 |
| KLK5, KLK6, KLK7, KLK14 | 皮肤屏障蛋白酶网络核心成员，介导角质层脱屑与屏障稳态，关联炎症性皮肤病 |
| KLK8, KLK9, KLK12, KLK13, KLK15 | 功能尚未完全阐明，在炎症和肿瘤进展中发挥作用 |
高纯度：经SDS-PAGE（≥95%）和SEC-MALS/HPLC验证
高酶活：酶活被纳入常规QC检测项，数据稳定可靠
高生物活性：高生物活性经ELISA验证
质量一致性：稳定保障研发过程中的质量一致性，为药物研发提供可靠支撑
抗体发现、免疫、抗体筛选及功能验证
小分子先导化合物的筛选
利用酶切活性进行检测底物的开发
Human Kallikrein 2 Protein, Tag Free (Cat.No. KA2-H5214) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
Biotinylated Human Kallikrein 3 Protein, His,Avitag (Cat.No. KA3-H82E4)on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
The purity of Human Kallikrein 3 Protein, His Tag (Cat. No. KL3-H52H3) is more than 95% and the molecular weight of this protein is around 25-40 kDa verified by SEC-MALS.
Protocol
The purity of Human Kallikrein 1 (25-262) Protein, His Tag (Cat. No. KL1-H52H4) was greater than 95% as determined by SEC-HPLC.
Protocol
| 测定产品 |
Human Kallikrein 2 Protein, Tag Free (active enzyme) (Cat.No.KA2-H5214) |
Human Kallikrein 2 Protein, His Tag (active enzyme) (Cat.No.KA2-H52H3) |
| 水解底物 | Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC) | |
|
酶活 （pmol/min/μg） |
>450 | >150 |
| 测定产品 |
Biotinylated Human Kallikrein 3 Protein, His,Avitag™ (active enzyme, MALS verified) (Cat.No.KA3-H82E4) |
Human Kallikrein 3 Protein, His Tag (Pro-form, MALS verified) (Cat.No.KL3-H52H3) |
| 水解底物 | Succinyl-Arg-Pro-Tyr-p-Nitroanilide (SucRPYpNA) | |
|
酶活 （pmol/min/μg） |
>160 | >150 |
| 测定产品 |
Human Kallikrein 5 Protein, Tag Free (active enzyme) (Cat.No.KA5-H5213) |
Human Kallikrein 7 Protein, Tag Free (active enzyme) (Cat.No.KA7-H5213) |
| 水解底物 | BOC-Val-Pro-Arg-AMC | Mca-RPKPVE-Nval-WRK(Dnp)-NH2 |
|
酶活 （pmol/min/μg） |
>350 | ＞150 |
Immobilized Human Kallikrein 2 Protein, Tag Free (Cat. No. KA2-H5214) at 1 μg/mL (100 μL/well) can bind Human KLK2 Antibody with a linear range of 0.1-8 ng/mL (Routinely tested).
Protocol
Immobilized Human Kallikrein 2 Protein, His Tag (Cat. No. KA2-H52H3) at 1 μg/mL (100 μL/well) can bind Human KLK2 Antibody, IgG with a linear range of 0.06-2 ng/mL (Routinely tested).
Protocol
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