Recombinant Proteins iso9001 ISO13485
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Rat ROR1 Protein, His Tag (MALS verified)

分子别名(Synonym)

ROR1,NTRKR1

表达区间及表达系统(Source)

Rat ROR1, His Tag (RO1-R5221) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403 (Accession # EDL97819).

Predicted N-terminus: Gln 30

蛋白结构(Molecular Characterization)

Online(Gln 30 - Glu 403) EDL97819

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 43.5 kDa. The protein migrates as 60-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Rat ROR1, His Tag (Cat. No. RO1-R5221) SDS-PAGE gel

Rat ROR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Rat ROR1, His Tag (Cat. No. RO1-R5221) MALS images

The purity of Rat ROR1, His Tag (Cat. No. RO1-R5221) was more than 90% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.

Report

背景(Background)

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

 

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ROR1靶点信息
英文全称:Inactive tyrosine-protein kinase transmembrane receptor ROR1
中文全称:蛋白酪氨酸激酶跨膜受体ROR1
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:6详情
最高研发阶段:临床二期
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