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 >  经MALS验证的蛋白>IL-21 R >ILR-H5226

Human IL-21 R Protein, His Tag (MALS verified)

分子别名(Synonym)

IL21R,CD360,NILR

表达区间及表达系统(Source)

Human IL-21 R, His Tag (ILR-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (Accession # Q9HBE5-1).

Predicted N-terminus: Cys 20

Request for sequence

蛋白结构(Molecular Characterization)

Online(Cys 20 - Pro 236) Q9HBE5-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 26.9 kDa. The protein migrates as 37-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human IL-21 R, His Tag (Cat. No. ILR-H5226) SDS-PAGE gel

Human IL-21 R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS

Human IL-21 R, His Tag (Cat. No. ILR-H5226) MALS images

The purity of Human IL-21 R, His Tag (Cat. No. ILR-H5226) is more than 90% and the molecular weight of this protein is around 40-50 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Biotinylated Human IL-21, Fc,Avitag (Cat. No. IL1-H82F7) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human IL-21 R, His Tag (Cat. No. ILR-H5226) with a linear range of 0.8-3 ng/mL (QC tested).

Protocol

背景(Background)

Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.

 

前沿进展

 
 
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IL-21 R靶点信息
英文全称:Interleukin 21 Receptor
中文全称:白介素21受体
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:临床一期
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