Recombinant Proteins iso9001 ISO13485
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Human IFN-alpha / beta R1 Protein, Fc Tag

分子别名(Synonym)

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

表达区间及表达系统(Source)

Human IFNAR1, Fc Tag (IF1-H5253) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # NP_000620).

Predicted N-terminus: Lys 28

蛋白结构(Molecular Characterization)

Online(Lys 28 - Lys 436) NP_000620

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 73.8 kDa. The protein migrates as 100-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human IFNAR1, Fc Tag (Cat. No. IF1-H5253) SDS-PAGE gel

Human IFNAR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

 

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IFN-alpha/beta R1靶点信息
英文全称:Interferon-alpha/beta receptor alpha chain
中文全称:干扰素α/β受体α链
种类:Homo sapiens
上市药物数量:3详情
临床药物数量:1详情
最高研发阶段:批准上市
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