Recombinant Proteins iso9001 ISO13485
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Human DR6 / TNFRSF21 Protein, Fc Tag

分子别名(Synonym)

TNFRSF21,DR6,CD358,BM-018

表达区间及表达系统(Source)

Human DR6, Fc Tag (TN1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Leu 350 (Accession # AAH17730).

Predicted N-terminus: Gln 42

蛋白结构(Molecular Characterization)

Online(Gln 42 - Leu 350) AAH17730

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 60.2 kDa. The protein migrates as 80-95kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human DR6, Fc Tag (Cat. No. TN1-H5252) SDS-PAGE gel

Human DR6, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.

 

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DR6靶点信息
英文全称:Tumor necrosis factor receptor superfamily member 21
中文全称:肿瘤坏死因子受体超家族成员21
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:无进展
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