描述/背景(Background)
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
种属(Host Species)
Rabbit
克隆号(Clone)
4A6
适用方法(Application)
IHC
效价(Property)
1:1000
状态(State)
Liquid
阳性对照(Positive Control)
Human Tonsil Tissues
克隆类型(Clonality)
Monoclonal
分子别名(Synonym)
CD19
研究领域(Research Field)
Cancer Drug Targets
抗体来源(Source)
Rabbit
同种型(Isotype)
IgG
储存(Storage)
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
典型数据(Typical Data)
质控样本(Control Sample)
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S259 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本(Cancer Sample)
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S259 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.