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 >  Antibody>CD19 >HGS-S259

Recombinant Monoclonal Anti-CD19 Antibody, Rabbit (4A6)

描述/背景(Background)

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.

种属(Host Species)

Rabbit

克隆号(Clone)

4A6

适用方法(Application)

IHC

效价(Property)

1:1000

状态(State)

Liquid

阳性对照(Positive Control)

Human Tonsil Tissues

克隆类型(Clonality)

Monoclonal

分子别名(Synonym)

CD19

研究领域(Research Field)

Cancer Drug Targets

抗体来源(Source)

Rabbit

同种型(Isotype)

IgG

储存(Storage)

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

 

典型数据(Typical Data)

质控样本(Control Sample)

CD19 CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S259 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

肿瘤样本(Cancer Sample)

CD19 CANCER SAMPLE

CD19 CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S259 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

 

前沿进展

 
 
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CD19靶点信息
英文全称:B-lymphocyte antigen CD19
中文全称:B淋巴细胞抗原CD19
种类:Homo sapiens
上市药物数量:10详情
临床药物数量:279详情
最高研发阶段:批准上市
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