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Human DKK-2 Protein, His Tag

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表达区间及表达系统(Source)

Human DKK-2 Protein, His Tag (DK2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Lys 34 - Ile 259 (Accession # Q9UBU2 ).

Predicted N-terminus: Lys 34

蛋白结构(Molecular Characterization)

DKK-2 Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 27 kDa.

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

背景(Background)

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. 

 

 
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