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 >  其他蛋白>IL-7 R alpha >ILA-H525a

Human IL-7 R alpha / CD127 Protein, Fc Tag

分子别名(Synonym)

IL7Ra,CD127

表达区间及表达系统(Source)

Human IL-7 R alpha, Fc Tag (ILA-H525a) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Asp 239 (Accession # P16871-1 ).

Predicted N-terminus: N/A

Request for sequence

蛋白结构(Molecular Characterization)

IL-7 R alpha Structure

This protein carries a human IgG1 Fc tag at the C-terminus

The protein has a calculated MW of 51.8 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with Trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

IL-7 R alpha SDS-PAGE

Human IL-7 R alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

 

活性(Bioactivity)-ELISA

IL-7 R alpha ELISA

Immobilized Human IL-7 Protein at 2 μg/mL (100 μL/well) can bind Human IL-7 R alpha, Fc Tag (Cat. No. ILA-H525a) with a linear range of 0.004-0.125 μg/mL (QC tested).

Protocol

背景(Background)

Interleukin-7 receptor subunit alpha (IL7Ra) is also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

 

前沿进展

 
 
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IL-7 R alpha靶点信息
英文全称:Interleukin-7 receptor subunit alpha
中文全称:白细胞介素-7受体α亚基
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:7详情
最高研发阶段:临床二期
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