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 >  Protein>CD45RA >CD5-H52H9

Human CD45RA / PTPRC protein, His Tag

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分子别名(Synonym)

B220, CD45, CD45R, GP180, IMD105, L-CA, LCA, LY5, T200

表达区间及表达系统(Source)

Human CD45RA / PTPRC protein, His Tag (CD5-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Lys 482 (Accession # P08575-8 ).

Predicted N-terminus: Gln 26

Request for sequence

蛋白结构(Molecular Characterization)

CD45RA Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 53.2 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

CD45RA SDS-PAGE

Human CD45RA / PTPRC protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 

背景(Background)

CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

 

前沿进展

 
 
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CD45RA靶点信息
英文全称:Leukocyte common antigen
中文全称:白细胞共同抗原
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:3详情
最高研发阶段:临床三期
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