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 >  Protein>LTBR >LTR-H5259

Human LTBR / TNFRSF3 Protein, Fc Tag

分子别名(Synonym)

LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

表达区间及表达系统(Source)

Human LTBR, Fc Tag (LTR-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Met 227 (Accession # P36941-1).

Predicted N-terminus: Gln 31

Request for sequence

蛋白结构(Molecular Characterization)

Online(Gln 31 - Met 227) P36941-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 48.8 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human LTBR, Fc Tag (Cat. No. LTR-H5259) SDS-PAGE gel

Human LTBR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Human LTBR, Fc Tag (Cat. No. LTR-H5259) at 5 μg/mL (100 μL/well) can bind Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LIT-H5256) with a linear range of 0.1-4 ng/mL (QC tested).

Protocol

背景(Background)

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

 

文献引用(Citations)

 

前沿进展

 
 
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LTBR靶点信息
英文全称:Tumor necrosis factor receptor superfamily member 3
中文全称:肿瘤坏死因子受体超家族成员3
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:终止
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