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 >  Protein>IL-17B >ILB-H5257

Human IL-17B Protein, Fc Tag (MALS verified)

分子别名(Synonym)

Interleukin-17B,Cytokine Zcyto7,Interleukin-20,IL-20,Neuronal interleukin-17-related factor,IL17B,IL20, NIRF, ZCYTO7

表达区间及表达系统(Source)

Human IL-17B, Fc Tag (ILB-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 21 - Phe 180 (Accession # Q9UHF5-1 ).

Predicted N-terminus: Gln 21

Request for sequence

蛋白结构(Molecular Characterization)

IL-17B Structure

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 44.6 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

IL-17B SDS-PAGE

Human IL-17B, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

IL-17B SEC-MALS

The purity of Human IL-17B, Fc Tag (Cat. No. ILB-H5257) is more than 85% and the molecular weight of this protein is around 90-105 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

IL-17B ELISA

Immobilized Human IL-17B, Fc Tag (Cat. No. ILB-H5257) at 1 μg/mL (100 μL/well) can bind Anti-Human IL17B Monoclonal Antibody with a linear range of 0.1-2 ng/mL (Routinely tested).

Protocol

 

背景(Background)

IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.

 

前沿进展

 
 
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IL-17B靶点信息
英文全称:Interleukin-17 receptor B
中文全称:白细胞介素-17受体B
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床一期
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