分子别名(Synonym)
Aromatic-L-amino-acid decarboxylase,Dopa decarboxilase,AADC
表达区间及表达系统(Source)
Human DDC, His Tag (DDC-H55H6) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Glu 480 (Accession # P20711-1).
Predicted N-terminus: Met 1
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.8 kDa.
内毒素(Endotoxin)
制剂(Formulation)
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运输(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 3 months under sterile conditions.
背景(Background)
Dopa decarboxilase (DDC), also known as aromatic amino acid decarboxylase, is a group II decarboxylase. The enzyme catalyzes the decarboxylation of aromatic L-amino acids to produce the corresponding amines. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. DDC inhibitors is in clinical use to treat Parkinson's disease(PD), usually co-administrated with L-DOPA. DDC would block peripheral conversion to dopamine and allow a greater percentage of L-DOPA to reach the brain, causing an increase in brain dopamine levels, and reducing the side effects of dopamine-rich blood.