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Human DDC / Dopa Decarboxilase Protein, His Tag

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分子别名(Synonym)

Aromatic-L-amino-acid decarboxylase,Dopa decarboxilase,AADC

表达区间及表达系统(Source)

Human DDC, His Tag (DDC-H55H6) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Glu 480 (Accession # P20711-1).

Predicted N-terminus: Met 1

蛋白结构(Molecular Characterization)

Online-Res(Met 1 - Glu 480) P20711-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 55.8 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
 

背景(Background)

Dopa decarboxilase (DDC), also known as aromatic amino acid decarboxylase, is a group II decarboxylase. The enzyme catalyzes the decarboxylation of aromatic L-amino acids to produce the corresponding amines. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. DDC inhibitors is in clinical use to treat Parkinson's disease(PD), usually co-administrated with L-DOPA. DDC would block peripheral conversion to dopamine and allow a greater percentage of L-DOPA to reach the brain, causing an increase in brain dopamine levels, and reducing the side effects of dopamine-rich blood.

 

 

前沿进展

 
 
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DDC靶点信息
英文全称:Aromatic-L-amino-acid decarboxylase
中文全称:DOPA脱羧酶
种类:Homo sapiens
上市药物数量:8详情
临床药物数量:8详情
最高研发阶段:批准上市
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