登录 | 注册    关注公众号  
微信公众号
搜索
 >  Protein>Monoamine oxidase B >MAB-H5547

Human MAOB / Monoamine Oxidase B Protein, His Tag (active enzyme)

分子别名(Synonym)

MAOB, MAO-B,Monoamine Oxidase B,Monoamine oxidase type B

表达区间及表达系统(Source)

Human MAOB, His Tag (MAB-H5547) is expressed from Baculovirus-Insect cells. It contains AA Ser 2 - Val 520 (Accession # P27338-1).

Predicted N-terminus: Met

Request for sequence

蛋白结构(Molecular Characterization)

Monoamine oxidase B Structure

This protein carries a polyhistidine tag at the N-terminus

The protein has a calculated MW of 60.6 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

This product is not suitable for cell based experiments due to cytotoxicity of DDM.
DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.
DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
*The isotype control of empty/mock nanodisc (Cat. No. APO-H51H3) is sold separately and not included in protein, you can follow this link for product information.
 

电泳(SDS-PAGE)

Monoamine oxidase B SDS-PAGE

Human MAOB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 

活性(Bioactivity)

Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >35 pmol/min/μg (QC tested).

背景(Background)

Monoamine Oxidase Type B (MAOB) is an enzyme located in the outer mitochondrial membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the breakdown of dopamine in the brain. MAOB inhibitors, that reduces dopamine turnover, are in clinical use for the treatment of Parkinsons disease (PD).

 

 

前沿进展

 
 
货号/价格
产品推荐
文档
联系电话:
+86 400-682-2521(全国)
010-53681107(北京)
021-50850665(上海)
运输方式
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
tech.cn@acrobiosystems.com
Monoamine oxidase B靶点信息
英文全称:Monoamine oxidase B
中文全称:单胺氧化酶B
种类:Homo sapiens
上市药物数量:4详情
临床药物数量:5详情
最高研发阶段:批准上市
查看更多信息
前沿进展
点击查看详细

消息提示

请输入您的联系方式,再点击提交!

确定