登录 | 注册    关注公众号  
微信公众号
搜索
 >  Protein>Neuropilin-2 >NR2-H52H3

Human Neuropilin-2 / NRP2 Protein, His Tag (MALS verified)

热销产品推荐:

ACROBiosystems提供针对多种生物标志物靶标的lHC抗体产品,具有:验证充分、质量可靠、灵活授权及免疫组化检测服务支持!

分子别名(Synonym)

Neuropilin-2,NRP2,VEGF165R2,Neuropilin2,Vascular endothelial cell growth factor 165 receptor 2

表达区间及表达系统(Source)

Human Neuropilin-2, His Tag (NR2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Pro 864 (Accession # O60462-1 ).

Predicted N-terminus: Arg 21

Request for sequence

蛋白结构(Molecular Characterization)

Neuropilin-2 Structure

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 97.0 kDa. The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Neuropilin-2 SDS-PAGE

Human Neuropilin-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Neuropilin-2 SEC-MALS

The purity of Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) is more than 90% and the molecular weight of this protein is around 98-128 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

Neuropilin-2 ELISA

Immobilized Human Neuropilin-2, His Tag (Cat. No. NR2-H52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165, His,Avitag (Cat. No. VE5-H82Q0) with a linear range of 0.005-0.625 μg/mL (QC tested).

Protocol

 

背景(Background)

Neuropilin-1 (Npn-1, previously known as neuropilin) and Neuropilin-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind distinct members of the class III secreted semaphorin subfamily that are implicated in repulsive axon guidance. Neuropilin extracellular domains contain two CUB (complement-binding) domains, two domains with homology to coagulation factors V and VIII, and a MAM (meprin) domain. In the absence of ligands, neuropilins can form homo- and hetero-oligomers via their MAM domains. Expression in developing neurons of the central and peripheral nervous systems is somewhat overlapping but distinct. Npn-1 and Npn-2 are also receptors for VEGF165 on endothelial and tumor cells.

 

前沿进展

 
 
货号/价格
产品推荐
文档
联系电话:
+86 400-682-2521(全国)
010-53681107(北京)
021-50850665(上海)
运输方式
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
tech.cn@acrobiosystems.com
Neuropilin-2靶点信息
英文全称:Neuropilin 2
中文全称:神经纤毛蛋白质-2
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床三期
查看更多信息
前沿进展
点击查看详细

消息提示

请输入您的联系方式,再点击提交!

确定