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 >  Protein>IL-20 >IL0-H5243

Human IL-20 Protein, His Tag (MALS & SPR verified)

分子别名(Synonym)

interleukin-20,IL10D,IL-20,interleukin 20,Cytokine Zcyto10,ZCYTO10

表达区间及表达系统(Source)

Human IL-20, His Tag (IL0-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Glu 176 (Accession # Q9NYY1-1).

Predicted N-terminus: His

Request for sequence

蛋白结构(Molecular Characterization)

IL-20 Structure

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 19.4 kDa. The protein migrates as 18 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

IL-20 SDS-PAGE

Human IL-20, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

IL-20 SEC-MALS

The purity of Human IL-20, His Tag (Cat. No. IL0-H5243) is more than 90% and the molecular weight of this protein is around 16-24 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-SPR

IL-20 SPR

Human IL-20, His Tag (Cat. No. IL0-H5243) immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

 

背景(Background)

Interleukin-20 (IL-20) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26. IL-20 induces STAT activation through two types of receptor complex, one of which it shares with IL-19, indicating that their biological activities may overlap. Both cytokines may play an important role in regulating the development and proper functioning of skin. IL-20 has also been shown to promote endothelial cell tube formation, suggesting that it may be involved in vascular vessel maturation and remodelling.

 

前沿进展

 
 
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IL-20靶点信息
英文全称:Interleukin 20
中文全称:白细胞介素20
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:终止
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