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Human FGF-23 (R179Q) Protein, His Tag

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分子别名(Synonym)

FGF23,HYPF,FGF-23,ADHR,HPDR2

表达区间及表达系统(Source)

Human FGF-23 (R179Q), His Tag (FG3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 251 (Accession # Q9GZV9-1 (R179Q)).

Request for sequence

蛋白结构(Molecular Characterization)

FGF-23 Structure

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 27.3 kDa. The protein migrates as 30-32 kDa and 33-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 20 mM MOPS, 150 mM NaCl, 5 mM EDTA, 2 mM DTT, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

FGF-23 SDS-PAGE

Human FGF-23 (R179Q), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

 

背景(Background)

Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. FGF23 and phosphate have been revealed to be factors relevant in cancer. FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.

 

前沿进展

 
 
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FGF-23靶点信息
英文全称:Fibroblast growth factor 23
中文全称:成纤维细胞生长因子-23
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:0详情
最高研发阶段:批准上市
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