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Mouse MERTK / Mer Protein, Fc Tag (MALS verified)

分子别名(Synonym)

MERTK,Mer,Gas6

表达区间及表达系统(Source)

Mouse MERTK, Fc Tag (MEK-M5253) is expressed from human 293 cells (HEK293). It contains AA Gly 19 - Met 497 (Accession # Q60805-1).

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蛋白结构(Molecular Characterization)

Online(Gly 19 - Met 497) Q60805-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 78.9 kDa. The protein migrates as 100-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by reduced SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse MERTK, Fc Tag (Cat. No. MEK-M5253) SDS-PAGE gel

Mouse MERTK, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Mouse MERTK, Fc Tag (Cat. No. MEK-M5253) MALS images

The purity of Mouse MERTK, Fc Tag (Cat. No. MEK-M5253) is more than 90% and the molecular weight of this protein is around 198-242 kDa verified by SEC-MALS.

Report

背景(Background)

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

 

 

前沿进展

 
 
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MERTK靶点信息
英文全称:Tyrosine-protein kinase Mer
中文全称:Mer受体酪氨酸激酶
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:6详情
最高研发阶段:批准上市
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