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Human Tau-441 / 2N4R (241-380) Protein, His Tag (MALS verified)

分子别名(Synonym)

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

表达区间及表达系统(Source)

Human Tau-441 (241-380), His Tag (TAU-H51H4) is expressed from E. coli cells. It contains AA Ser 241 - Glu 380 (Accession # P10636-8).

Predicted N-terminus: Met

Request for sequence

蛋白结构(Molecular Characterization)

Online(Ser 241 - Glu 380) P10636-8

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 16.9 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5 . Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human Tau-441 (241-380), His Tag (Cat. No. TAU-H51H4) SDS-PAGE gel

Human Tau-441 (241-380), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Human Tau-441 (241-380), His Tag (Cat. No. TAU-H51H4) MALS images

The purity of Human Tau-441 (241-380), His Tag (Cat. No. TAU-H51H4) is more than 90% and the molecular weight of this protein is around 15-23 kDa verified by SEC-MALS.

Report

背景(Background)

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

 

 

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Tau靶点信息
英文全称:Microtubule-associated protein tau
中文全称:微管相关蛋白tau
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:36详情
最高研发阶段:批准上市
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