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 >  经MALS验证的蛋白>BCMA >BCA-C52H3

Canine BCMA / TNFRSF17 Protein,His Tag (MALS verified)

分子别名(Synonym)

TNFRSF17,CD269,BCM,BCMA

表达区间及表达系统(Source)

Canine BCMA, His Tag (BCA-C52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asn 44 (Accession # Q02223-1 ).

Request for sequence

蛋白结构(Molecular Characterization)

BCMA Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 7.1 kDa. The protein migrates as 10-12 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

BCMA SDS-PAGE

Canine BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

BCMA SEC-MALS

The purity of Canine BCMA, His Tag (Cat. No. BCA-C52H3) is more than 85% and the molecular weight of this protein is around 7-12 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

BCMA ELISA

Immobilized Canine BCMA, His Tag (Cat. No. BCA-C52H3) at 5 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

BCMA ELISA

Immobilized Canine BCMA, His Tag (Cat. No. BCA-C52H3) at 5 μg/mL (100 μL/well) can bind Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) with a linear range of 0.02-0.313 μg/mL (Routinely tested).

Protocol

BCMA ELISA

Immobilized Human APRIL, Fc Tag (Cat. No. APL-H5267) at 5 μg/mL (100 μL/well) can bind Canine BCMA, His Tag (Cat. No. BCA-C52H3) with a linear range of 0.2-1 ng/mL (Routinely tested).

Protocol

背景(Background)

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

 

前沿进展

 
 
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BCMA靶点信息
英文全称:B-cell maturation protein
中文全称:B细胞成熟蛋白
种类:Homo sapiens
上市药物数量:2详情
临床药物数量:58详情
最高研发阶段:批准上市
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