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Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free

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分子别名(Synonym)

Integrin alpha L beta 2,ITGAL&ITGB2

表达区间及表达系统(Source)

Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W6) is expressed from human 293 cells (HEK293). It contains AA Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2) (Accession # P20701-1(ITGAL) & P05107-1(ITGB2)).

蛋白结构(Molecular Characterization)

Online-Res(Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2)) P20701-1 (ITGAL) & P05107-1 (ITGB2)

Human ITGAL & ITGB2 Heterodimer Protein, produced by co-expression of ITGAL and ITGB2, has a calculated MW of 124.2 kDa (ITGAL) & 80.1 kDa (ITGB2). Subunit ITGAL is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

 

前沿进展

 
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Integrin alpha L beta 2靶点信息
英文全称:Integrin alpha-L/beta-2 (LFA-1)
中文全称:整合素α-L/β-2复合体(LFA-1)
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:0详情
最高研发阶段:批准上市
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