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 >  Protein>CLEC12A >CLA-M5244

Mouse CLEC12A / MICL / CLL-1 Protein, His Tag

分子别名(Synonym)

CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371

表达区间及表达系统(Source)

Mouse CLEC12A, His Tag (CLA-M5244) is expressed from human 293 cells (HEK293). It contains AA Tyr 65 - Arg 267 (Accession # Q504P2-1).

Predicted N-terminus: His

Request for sequence

蛋白结构(Molecular Characterization)

Online(Tyr 65 - Arg 267) Q504P2-1

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 25.7 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse CLEC12A, His Tag (Cat. No. CLA-M5244) SDS-PAGE gel

Mouse CLEC12A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

 

 

前沿进展

 
 
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CLEC12A靶点信息
英文全称:C-Type lectin domain family 12 member A
中文全称:C型凝集素结构域家族12成员A
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:20详情
最高研发阶段:临床三期
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