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 >  Protein>IL-13 R alpha 2 >IL2-R52H5

Rhesus macaque IL-13 R alpha 2 Protein, His Tag

分子别名(Synonym)

IL13RA2,CD213A2,CT19,IL-13R,IL13BP

表达区间及表达系统(Source)

Rhesus macaque IL-13 R alpha 2, His Tag (IL2-R52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 26 - Ther 340 (Accession # XP_014983540.1 ).

Predicted N-terminus: Ser 26

Request for sequence

蛋白结构(Molecular Characterization)

IL-13 R alpha 2 Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 40.0 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

IL-13 R alpha 2 SDS-PAGE

Rhesus macaque IL-13 R alpha 2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 

活性(Bioactivity)-ELISA

IL-13 R alpha 2 ELISA

Immobilized Rhesus macaque IL-13 R alpha 2, His Tag (Cat. No. IL2-R52H5) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-IL-13 R alpha 2 Antibody, Mouse IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

 

背景(Background)

Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.

 

前沿进展

 
 
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IL-13 R alpha 2靶点信息
英文全称:Interleukin-13 receptor subunit alpha-2
中文全称:白细胞介素-13受体α2亚基
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:5详情
最高研发阶段:临床一期
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