Recombinant Proteins iso9001 ISO13485
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Human BMPR-IA / ALK-3 Protein, His Tag

分子别名(Synonym)

BMPR-1A,ALK-3,10q23del,ACVRLK3,CD292,SKR5

表达区间及表达系统(Source)

Human BMPR-IA, His Tag (AL3-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # P36894-1).

Predicted N-terminus: Gln 24

蛋白结构(Molecular Characterization)

Online(Gln 24 - Arg 152) P36894-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 15.0 kDa. The protein migrates as 23-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human BMPR-IA, His Tag (Cat. No. AL3-H5228) SDS-PAGE gel

Human BMPR-IA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

 

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BMPR-IA靶点信息
英文全称:Bone morphogenetic protein receptor type-1A
中文全称:1A型骨形态发生蛋白受体
种类:Homo sapiens
上市药物数量:2详情
临床药物数量:0详情
最高研发阶段:批准上市
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