Recombinant Proteins iso9001 ISO13485
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Human Bcl-x / BCL2L1 Protein, GST Tag

分子别名(Synonym)

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL/S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

表达区间及表达系统(Source)

Human Bcl-x, GST Tag (BC1-H513a) is expressed from E.coli cells. It contains AA Ser 2 - Arg 212 (Accession # AAH19307).

Predicted N-terminus: Met

蛋白结构(Molecular Characterization)

Online(Ser 2 - Arg 212) AAH19307

This protein carries a GST tag at the N-terminus.

The protein has a calculated MW of 50.6 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>92% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, pH7.5 with 10 mM GSH. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human Bcl-x, GST Tag (Cat. No. BC1-H513a) SDS-PAGE gel

Human Bcl-x, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

背景(Background)

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

 

前沿进展

 
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Bcl-x靶点信息
英文全称:Apoptosis regulator Bcl-X
中文全称:Bcl-X蛋白
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:2详情
最高研发阶段:临床二期
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