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 >  Protein>Bcl-x >BC1-H5120

Human Bcl-x / BCL2L1 Protein, His Tag

分子别名(Synonym)

BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL,S,BCL2L,BCLX,BCLXL,BCLXS,Bcl-X,bcl-xS

表达区间及表达系统(Source)

Human Bcl-x, His Tag (BC1-H5120) is expressed from E. coli cells. It contains AA Met 1 - Arg 212 (Accession # AAH19307 ).

Predicted N-terminus: Met 1

Request for sequence

蛋白结构(Molecular Characterization)

Bcl-x Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 24.6 kDa. The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 20 mM HEPES, 50 mM KCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Bcl-x SDS-PAGE

Human Bcl-x, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 

背景(Background)

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

 

前沿进展

 
 
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Bcl-x靶点信息
英文全称:Apoptosis regulator Bcl-X
中文全称:Bcl-X蛋白
种类:Homo sapiens
上市药物数量:2详情
临床药物数量:7详情
最高研发阶段:批准上市
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