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 >  Protein>Properdin >PRN-M52H5

Mouse Properdin Protein, His Tag

分子别名(Synonym)

Properdin,Complement factor P,CFP,PFC

表达区间及表达系统(Source)

Mouse Properdin, His Tag (PRN-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 23 - Pro 464 (Accession # P11680-1).

Predicted N-terminus: Ser 23

Request for sequence

蛋白结构(Molecular Characterization)

Online(Ser 23 - Pro 464) P11680-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 49.8 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse Properdin, His Tag (Cat. No. PRN-M52H5) SDS-PAGE gel

Mouse Properdin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.

 

 

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Properdin靶点信息
英文全称:Properdin
中文全称:备解素
种类:
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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