Human Her2 / ErbB2 Protein, Tag Free

文献引用（Citations）

• PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates

  Authors: Li Q, Li W, Xu K, et al.

  Journal: International journal of molecular sciences 2021

  Application: ELISA

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• Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids

  Authors: Turner, Brendan L et al.

  Journal: Analytical chemistry 2020

  Application: Dual-Affinity Ratiometric Quenching (DARQ) Assay

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• Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab

  Authors: Hutterer KM, et al.

  Journal: BioDrugs 43565

  Application: ELISA

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背景（Background）

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .