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 >  Protein>Prolactin R >PRR-H52Ha

Human Prolactin R / PRLR Protein, His Tag

分子别名(Synonym)

Prolactin R,PRLR,PRL-R

表达区间及表达系统(Source)

Human Prolactin R, His Tag (PRR-H52Ha) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1 ).

Predicted N-terminus: Gln 25

Request for sequence

蛋白结构(Molecular Characterization)

Prolactin R Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 26.3 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Prolactin R SDS-PAGE

Human Prolactin R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

Prolactin R ELISA

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 20-156 ng/mL (QC tested).

Protocol

Prolactin R ELISA

Immobilized Human GH, Tag Free at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 0.313-5 μg/mL (Routinely tested).

Protocol

 

背景(Background)

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

 

前沿进展

 
 
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Prolactin R靶点信息
英文全称:Prolactin receptor
中文全称:催乳素受体
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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