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CD39信息

英文名称:Ectonucleoside triphosphate diphosphohydrolase 1
中文名称:外核苷三磷酸二磷酸水解酶-1
靶点别称:ENTPD1,Ecto-ATPDase 1,CD39,Ecto-ATPase 1,NTPDase 1,Ectonucleoside triphosphate diphosphohydrolase 1,CD_antigen=CD39,Ecto-ATP diphosphohydrolase 1,Ecto-apyrase,Lymphoid cell activation antigen
上市药物数量:0
临床药物数量:3
最高研发阶段:临床一期

CD39产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD9-H52H4
Human
Human CD39 / ENTPD1 Protein, His Tag
CD9-H82E5
Human
Biotinylated Human CD39 / ENTPD1 Protein, His,Avitag (MALS verified)
CD9-H5253
Human
Human CD39 Protein, Mouse IgG2a Fc Tag
 
评论(1)
CD9-H52H4|Human CD39 / ENTPD1 Protein, His Tag
  1. 136XXXXXXX6
  2. 7人赞
  3. 购买蛋白用于测试CD39封闭性抗体封闭CD39水解ATP的功能实验。通过系列梯度CD39抗体与一定浓度的CD39(0.5ug/ml)孵育,再加入50uM ATP,用CTG检测,得到很好的曲线。证明该蛋白具有很好的ATP酶水解功能。
  4. 2019-11-11
 

CD39 Molecule Synonym Name

CD39, ENTPD1, NTPDase 1, Entpd1, Ecto-ATPDase 1, Ecto-ATPase 1

CD39 分子背景

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

CD39 参考文献

CD39临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
SRF-617 SRF-617 临床一期 Surface Oncology 癌症 详情
IPH-5201 IPH-5201,IPH5201 临床一期 INSERM, Orega Biotech, 阿斯利康, Innate 晚期实体瘤 详情
TTX-030 TTX-030,TTX030 临床一期 Tizona Therapeutics, 艾伯维 癌症 详情

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