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Fc gamma RIIB / CD32b信息

英文名称:Low affinity immunoglobulin gamma Fc region receptor II-b
中文名称:低亲和力免疫球蛋白γFc区受体II-B
靶点别称:FCGR2C,Fc-Gamma-RIIc,IgG Fc Receptor II-C,Fc-gamma-RIIb,FCGR2B,IGFR2,CD32,Fc Fragment Of IgG Receptor IIb,Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32),Fc Gamma Receptor IIb,IgG Fc Receptor II-B,Fc-Gamma RII-B,FcRII-B,CDw32,FCG2,Low Affinity Immun
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

Fc gamma RIIB / CD32b Molecule Synonym Name

FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32

Fc gamma RIIB / CD32b 分子背景

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Fc gamma RIIB / CD32b 参考文献

Fc gamma RIIB / CD32b临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Obexelimab AMG-729; XmAb-5871 临床三期 Xencor 免疫球蛋白G4相关疾病, 类风湿关节炎, 自身免疫疾病, 系统性红斑狼疮 详情
PRV-3279 MGD-010; PRV-3279; CD32BxCD-79B 临床二期 Macrogenics 自身免疫疾病, 系统性红斑狼疮 详情
BI-1206 6G-11; BI-1206 临床二期 Bioinvent International B-细胞淋巴瘤, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病 详情

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