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EphB4信息

英文名称:Ephrin type-B receptor 4
中文名称:B型肝配蛋白受体-4
靶点别称:TYRO11,EPHB4,Tyrosine-protein kinase TYRO11,Ephrin type-B receptor 4,MYK1,Hepatoma transmembrane kinase,HTK
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

EphB4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
EP4-H8229
Human
Recombinant Human EphB4 / MYK1 / TYRO11 Protein, Biotinylated
EP4-H5229
Human
Human-EPHB4-Protein

EphB4 分子别名

EphB4,HTK,MYK1,TYRO11

EphB4 分子背景

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

EphB4 参考文献

EphB4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
JI-101 JI-101; CGI-1842,JI101,CGI-1842 临床二期 吉利德, Jubilant Innovation 实体瘤 详情
sEphB4-HSA Vas-01; sEphB4-HSA 临床二期 VasGene, 美国国立癌症研究所, 南加州大学 实体瘤, Kaposis肉瘤 详情
TG-100801 TG-100801 临床二期 赛诺菲 年龄相关性黄斑变性 详情
TG-100572 TG-100572 临床二期 赛诺菲 年龄相关性黄斑变性

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