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CTGF信息

英文名称:Connective Tissue Growth Factor
中文名称:结缔组织生长因子
靶点别称:HCS24,IGFBP8,IGF-binding protein 8,CCN2 ,Insulin-like growth factor-binding protein 8,Hypertrophic chondrocyte-specific protein 24,IGFBP-8,Connective tissue growth factor,IBP-8,CTGF,CCN family member 2
上市药物数量:2
临床药物数量:9
最高研发阶段:批准上市

CTGF Molecule Synonym Name

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

CTGF 分子背景

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF 参考文献

CTGF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Netarsudil Dimesylate AR-13324; AR-13224,AR13324 批准上市 Aerie Pharmaceuticals RHOPRESSA fda 高眼压症, 开角型青光眼 AERIE PHARMS INC 2017-12-18 高眼压症, 开角型青光眼 详情
Netarsudil mesylate/Latanoprost PG-324 批准上市 Aerie Pharmaceuticals ROCKLATAN fda AERIE PHARMS INC 2019-03-12 高眼压症, 青光眼 详情

CTGF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Setogepram PBI-4050 临床三期 Prometic Life Sciences Alstrom综合征 详情
OLX-10010 OLX-10010; BMT-101; OLX-101; cp-asiCTGF 临床二期 OliX Pharmaceuticals, Hugel 皮肤增生性瘢痕 详情
ALT-0701 ALT-0701 临床二期 AltruGen 纤维化
RXI-109 RXI-109 临床二期 RXi Pharmaceutical 皮肤瘢痕 详情
OLX-701 OLX-701 临床前 OliX Pharmaceuticals 肝纤维化
EXC-001 EXC-001; PF-06473871; PF-6473871 临床二期 Ionis, 辉瑞 皮肤增生性瘢痕 详情
Pamrevlumab FG-3019 临床三期 FibroGen 特发性肺纤维化, 胰腺癌 详情
OLX-201 OLX-201,OLX 201,OLX201 临床前 Korea Institute of Toxicology, OliX Pharmaceuticals 特发性肺纤维化
OLX-301 OLX-301,OLX301; OLX 301 临床前 OliX Pharmaceuticals 纤维化, 年龄相关性黄斑变性

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