搜索
 > 【GP120】重组蛋白信息

GP120信息

英文名称:Envelope glycoprotein gp160
中文名称:包膜糖蛋白gp160
靶点别称:gp120,Transmembrane protein gp41,SU,TM,Envelope glycoprotein gp160,Surface protein gp120,env,Glycoprotein 120
上市药物数量:2
临床药物数量:20
最高研发阶段:批准上市

GP120产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GP4-V15227
HIV-1 (CN54)
HIV-1 [HIV-1/Clade B/C (CN54)] GP120 Protein, His Tag
GP0-V182E6
HIV-1 (CN54)
Biotinylated HIV-1 [HIV-1/Clade B/C (CN54)] GP120 Protein, His,Avitag
 
评论(0)
 

GP120 Molecule Synonym Name

GP120,GP120-CN54

GP120 分子背景

Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry. Three gp120s, bound as heterodimers to a transmembrane glycoprotein, gp41, are thought to combine in a trimer to form the envelope spike, which is involved in virus-cell attachment. One half of the molecular weight of gp120 is due to the carbohydrate side chains (the "glyco-" in "glycoprotein"). These are sugar residues which form something almost like a sugar "dome" over the gp120 spikes. This dome prevents gp120 from being recognised by the human immune response. As the HIV virus and the human CD4 cell come together, the gp120 binding site "snaps open" at the last minute.The glycoprotein gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells by binding to CD4 receptors, particularly helper T-cells. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

GP120 参考文献

GP120上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Astodrimer sodium 阿斯君默钠阴道生物性黏附凝胶 BRI-7013; SPL-7013 批准上市 Biomolecular Research Institute, Starpharma, Aspen 细菌性阴道炎 详情
Fostemsavir BMS-663068; GSK 3684934; BMS 626529 prodrug; 97IQ273H4L (UNII code) 批准上市 百时美施贵宝, ViiV Healthcare RUKOBIA fda VIIV HLTHCARE 2020-07-02 艾滋病 详情

GP120临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
F-105 F-105 临床一期 Centocor 艾滋病 详情
AD 519 AD-519; CGP-56134 临床二期 Tanox 艾滋病
CAP256V2S CAP256V2S; VRC-HIVMAB0102-00-AB 临床一期 国家过敏和传染病研究所, The Centre for the AIDS Programme of Research in South Africa (CAPRISA) 艾滋病 详情
HIV gp160 vaccine 临床一期 赛诺菲巴斯德 艾滋病 详情
Sifuvirtide SFT; FS-0101 临床三期 天津市扶素生物技术 艾滋病
HIV gp120 vaccine (ID Biomedical) 临床一期 Albert Einstein College of Medicine, ID Biomedical, TheraGuide 艾滋病
KD-247 KD-247 临床一期 Kaketsuken, Kumamoto University, 密苏里大学 艾滋病 详情
AD-439 CGP-47439; AD-439 临床二期 Tanox, 诺华 艾滋病
RAP-102 RAP-102; KLH-RAP 101,RAP 102,RAP102 临床一期 RAPID Pharmaceuticals 艾滋病, 多发性硬化症
BMS-378806 BMS-378806; BMS-806 临床一期 百时美施贵宝 艾滋病 详情
DNA-4 HIV vaccine (The Biomedical Center) DNK-4,DNK 4,DNK4 临床二期 生物医学中心(俄罗斯圣彼得堡) 艾滋病
ALVAC-vCP125 ALVAC vCP-125; vCP-125 临床一期 赛诺菲, Merck, Virogenetics 艾滋病
JNJ-53718678 JNJ-53718678; JNJ-678 临床二期 强生 合胞体病毒感染 详情
CSW-1 CSW-1 临床前 Autoimmune Technologies, Tulane University School of Medicine 肺炎SARS, 中东呼吸道综合征病毒感染, 冠状病毒感染
Alvircept sudotox (Pharmacia Corporation) CD4-PE; CD4(178)-PE40; SCD4(178)-PE40; sCD4-PE40; ACTG-201; U-85855 临床一期 辉瑞 艾滋病 详情
Monoclonal antibody NM01 临床一期 SRD Pharmaceuticals 艾滋病
HIV-1 Rgp-160 vaccine 临床一期 国家过敏和传染病研究所 艾滋病 详情
TR-291144 TR-290999; TR-291144; TRI-1144 临床一期 亚力兄制药, 罗氏 艾滋病
Sulfated polymannuroguluronate 临床二期 中国海洋大学, 青岛海大科技制药有限公司 艾滋病
MB-66 MB-66; Mapp-66 临床一期 Mapp Biopharmaceutical 艾滋病, 单纯疱疹感染 详情

消息提示

请输入您的联系方式,再点击提交!

确定