Galectin-4 分子别名
LGALS4,L36LBP,Gal-4,Antigen NY-CO-27,Lactose-binding lectin 4
Galectin-4 分子背景
Galectin-4 (Gal-4), also known as L36LBP (L-36 lactose-binding protein). The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer.
Galectin-4 前沿进展
- Barondes SH., et al., 1994, J. Biol. Chem. 269 (33): 20807-20810.
- Yang, RY., et al., 2008, Expert Rev. Mol. Med. 10: e17.
- Ideo H., et al., 2007, J. Biol. Chem. 282 (29): 21081-21089.