TSLP 靶点蛋白|抗体药物|临床药物信息

TSLP信息

英文名称：Thymic stromal lymphopoietin
中文名称：胸腺基质淋巴细胞生成素
靶点别称：Thymic stromal lymphopoietin，TSLP

上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期

TSLP产品列表

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在线 (8)

物种

标签

属性

Protein (8)

标记

货号	物种	产品描述
TSP-H82Eb	Human	Biotinylated Human TSLP Protein, His,Avitag
TSP-H52Hb	Human	Human TSLP Protein, His Tag
TSP-H52Ha	Human	Human TSLP (R127A, R130A) Protein, His Tag
TSP-H82E0	Human	Biotinylated Human TSLP (R127A, R130A) Protein, His,Avitag
TSP-H5255	Human	Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag
TSP-M52H8	Mouse	Mouse TSLP Protein, His Tag
TSP-C52H4	Cynomolgus	Cynomolgus TSLP (R127A, R130S) Protein, His Tag
TSP-C52H8	Cynomolgus	Cynomolgus TSLP Protein, His Tag

TSLP Molecule Synonym Name

TSLP

TSLP 分子背景

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

TSLP 参考文献

TSLP临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Tezepelumab	AMG-157; MEDI-9929	临床三期	安进	阻塞性肺疾病, 肺疾病, 哮喘, 呼吸道超敏反应, 支气管疾病, 速发型超敏反应, 慢性阻塞性肺疾病, 特应性皮炎, 超敏反应	详情

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TSLP 重组蛋白