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TSLP信息

英文名称:Thymic stromal lymphopoietin
中文名称:胸腺基质淋巴细胞生成素
靶点别称:TSLP
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

TSLP Molecule Synonym Name

TSLP

TSLP 分子背景

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

TSLP 参考文献

TSLP临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RG-7258 RG-7258 临床一期 罗氏 哮喘
Tezepelumab AMG-157; MEDI-9929 临床三期 安进, 阿斯利康 哮喘 详情

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