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IL-21信息

英文名称:Interleukin-21
中文名称:白细胞介素-21
靶点别称:Za11,IL-21,Interleukin 21,Interleukin-21 Isoform,CVID11
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

IL-21产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL1-H82F7
Human
Biotinylated Human IL-21 Protein, Fc,Avitag (MALS verified)
IL1-H5253
Human
Human IL-21 Protein, Fc Tag
 
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IL-21 Molecule Synonym Name

IL21,Za11,Interleukin-21

IL-21 分子背景

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

IL-21 参考文献

IL-21临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
NN-9828 NN-8828; NN-9828; Anti-IL21; NNC114-0005; NNC0114-0006; NNC-0114-0000-0005 临床二期 百时美施贵宝 1型糖尿病, 类风湿关节炎, 系统性红斑狼疮, 炎性疾病, 克罗恩病, 糖尿病 详情
IL-21 mab (Lilly) 临床一期 礼来制药 免疫紊乱
BOS-161721 BOS-161721 临床二期 Medimmune, Boston Pharmaceuticals 自身免疫疾病, 系统性红斑狼疮 详情

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