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M-CSF信息

英文名称:Macrophage Colony Stimulating Factor 1
中文名称:巨噬细胞集落刺激因子-1
靶点别称:CSF-1,M-CSF,MCSF,Processed macrophage colony-stimulating factor 1
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

M-CSF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MCF-H5247
Human
Human M-CSF / CSF-1 Protein, His Tag
MCF-H82E6
Human
Biotinylated Human M-CSF / CSF-1 Protein, His,Avitag
 
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M-CSF Molecule Synonym Name

M-CSF,CSF-1,Lanimostim

M-CSF 分子背景

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. Macrophage colony-stimulating factor has been shown to interact with PIK3R2. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.

M-CSF 参考文献

M-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Lacnotuzumab MCS-110 临床二期 诺华 骨转移性实体瘤, 前列腺癌, 乳腺癌, 实体瘤, 腱鞘骨巨细胞瘤, 色素沉着绒毛结节性滑膜炎 详情
Granulocyte-macrophage colony stimulating factor (Otsuka Pharmaceutical) 临床一期 大冢制药 免疫刺激剂
Sargramostim therapy (Innoventus Project) 临床一期 Innoventus Project 牙周炎
PD-360324 PD-360324; PD-0360324 临床二期 辉瑞 实体瘤 详情

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