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 > 【SCF】重组蛋白信息

SCF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
SCF-H4212
Human
Human SCF /KITLG Protein,HEK293 expressed,ActiveMax
SCF-M5228
Mouse
Recombinant Mouse SCF / KITLG Protein
SCF-H82E1
Human
Biotinylated Human SCF / KITLG Protein, His Tag, Avi Tag

SCF 分子别名

KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL

SCF 分子背景

Kit ligand (KITLG) is also known as stem cell factor (SCF), mast cell growth factor (MGF), steel factor (SF), which belongs to the SCF family, and is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. KITLG is the ligand for the receptor-type protein-tyrosine kinase KIT. SCF / MGF plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG / SCF binding can activate several signaling pathways. KITLG / SF Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG / SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG / SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG / SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5 - trisphosphate. KITLG / SCF acts synergistically with other cytokines, probably interleukins.

SCF 参考文献

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