Kit ligand (KITLG) is also known as stem cell factor (SCF), mast cell growth factor (MGF), steel factor (SF), which belongs to the SCF family, and is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. KITLG is the ligand for the receptor-type protein-tyrosine kinase KIT. SCF / MGF plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG / SCF binding can activate several signaling pathways. KITLG / SF Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG / SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG / SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG / SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5 - trisphosphate. KITLG / SCF acts synergistically with other cytokines, probably interleukins.
- Lu H.S., et al., 1992, Arch. Biochem. Biophys. 298:150-158.
- Wang Z.-Q., et al., 2009, Am. J. Hum. Genet. 84:672-677.
- Lev S., et al., 1992, J. Biol. Chem. (UNITED STATES) 267 (15): 10866–73.
- Anderson DM, et al., 1991, Cell Growth Differ. 2 (8): 373–8.
- Broudy VC, 1997, Blood 90 (4): 1345–64.
- Blouin R, Bernstein A, 1993, In Freedman MH, Feig SA. Boca Raton: CRC Press.
- Kent D, et al., 2008, Clin. Cancer Res. 14 (7): 1926–30.