搜索
 > 【BAFFR】重组蛋白信息

BAFFR信息

英文名称:B-cell activating factor receptor
中文名称:B细胞活化因子受体
靶点别称:BAFF-R,TNFRSF13C,BAFFR,BR3,B-cell-activating factor receptor,BAFF receptor,BLyS receptor 3,CD268
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

BAFFR Molecule Synonym Name

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

BAFFR 分子背景

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

BAFFR 参考文献

BAFFR临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Briobacept 临床二期 百健艾迪, 基因泰克 慢性淋巴细胞白血病, 干燥综合征, 类风湿性关节炎
Ianalumab NOV-5; VAY-736 临床三期 MorphoSys, 诺华 自身免疫性肝炎 详情

消息提示

请输入您的联系方式,再点击提交!

确定