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DDR2信息

英文名称:Discoidin domain-containing receptor 2
中文名称:盘状结构域受体-2
靶点别称:TKT,Discoidin domain receptor 2,Discoidin domain-containing receptor tyrosine kinase 2,Receptor protein-tyrosine kinase TKT,NTRKR3 ,Neurotrophic tyrosine kinase, receptor-related 3,TYRO10,CD167 antigen-like family member B,CD_antigen=CD167b,Tyrosine-prote
上市药物数量:1
临床药物数量:0
最高研发阶段:批准上市

DDR2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
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DDR2 分子别名

DDR2,CD167b,NTRKR3,TKT,TYRO10

DDR2 分子背景

Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

DDR2 参考文献

DDR2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Regorafenib Monohydrate 瑞戈非尼 BAY-73-4506; DAST,BAY73-4506,BAY 73-4506,BAY-734506 批准上市 拜耳, 奥尼克斯制药 STIVARGA fda 胃肠道间质瘤, 转移性结直肠癌 BAYER HLTHCARE 2012-09-27 胃肠道间质瘤, 肝癌, 转移性结直肠癌, 肝细胞癌 详情

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